Summary of: Khozin S, Miksad RA, Adami J, Boyd M, Brown NR, Gossai A, Kaganman I, Kuk D, Rockland JM, Pazdur R, Torres AZ, Zhi J, Abernethy AP. Real-world progression, treatment, and survival outcomes during rapid adoption of immunotherapy for advanced non-small cell lung cancer. Cancer. 2019;125(22):4019-4032.
With FDA collaborators, Flatiron researchers applied a previously published method for capturing cancer progression from EHRs to a large group of de-identified patients with aNSCLC treated with immune checkpoint inhibitors.
The current analysis provides rich insights on early adoption of immunotherapy. Some notable findings include rapid shifts in practice patterns (0 percent in Q3 2014 to 42 percent in Q2 2017), outcomes in patient subsets underrepresented in trials (hepatic dysfunction associated with worse survival) and relevance of intermediate endpoints: real-world time to treatment discontinuation may correlate more closely with overall survival than real-world progression-free survival.