Summary of: Griffith SD, Tucker MG, Bowser B, Calkins G, Chang C, Guardino E, Khozin S, Kraut J, You P, Schrag D, Miksad RA. Generating real-world tumor burden endpoints from electronic health record data: Comparison of RECIST, radiology-anchored, and clinician-anchored approaches for abstracting real-world progression in non-small cell lung cancer. Adv Ther. 2019;36(8):2122-2136.
In collaboration with the FDA, Dana-Farber Cancer Institute and Genentech, Flatiron evaluated methods to capture progression outcomes based on the documents in the electronic health record. This study found that the application of strict RECIST clinical trial radiology interpretation rules was not viable; however, capturing the clinician’s written assessment of the patient’s cancer status was a feasible and reliable method for understanding progression.