Learn real-world evidence.

RWD Basics

Essentials for getting started with RWE.

Start with the basics

Uses in oncology

  • Trial design
  • Biomarker prioritization
  • Post marketing requirements and commitments
  • Label expansion
Start with uses in oncology

RWD basics

Real-world data is different.

The path to understanding real-world evidence starts at the point of care. Unlike data sourced from clinical trials, real-world data (RWD) are typically recorded in support of a patient’s treatment plan rather than according to a particular research protocol. This means that key insights may lie scattered across annotated radiology reports or physicians’ notes.

Without careful effort to process and verify these data, RWD may be subject to gaps and biases, rendering the data unfit for use. To succeed with RWD, researchers must first understand the quality challenges, impacts, and what measures must be taken to assure its fitness for use in the context of their research or regulatory questions.

This collection covers the fundamentals of RWD including its generation and how it's ultimately being used by life science companies, regulators and other decision-making bodies throughout the oncology drug development lifecycle.

RWE in Oncology

Using real-world evidence today.

Browse related research, case studies and other resources that highlight examples of how RWE is being used today.

Trial design

Clinical trials can provide the most definitive and robust evidence for efficacy and safety. In 2021, the average oncology phase 3 study costs nearly 250 million dollars and takes more than 3 years to read out. Today, RWD is helping to improve trial designs decisions and accelerate drug development timelines. Read this collection to learn how researchers are using RWD to predict control arm performance, establish protocols according to the latest standards of care and more.

  • expert insightAsset 6 Article
    Real-world data and the case of the missing deaths

    Overall survival is a key endpoint in clinical trials. But when using RWD, how is missing data addressed?

    21 min read

  • publication summaryAsset 5 Publication Summary
    Comparative effectiveness with RWD?

    RWD can enhance health technology appraisals by providing population-level evaluations of cancer therapies. This enables researchers to select comparator populations and inform clinical trial design.

    8 min read

  • publication summaryAsset 5 Publication Summary
    How rapid adoption of IO impacted outcomes in the real world

    Real-world data is curated to track novel therapies in real-time, when registries may lag for years. This makes it possible to anticipate and design trials based on actual current outcomes.

    9 min read

  • videoAsset 7 Video
    Use of a clinico-genomic database (CGDB) for R&D

    Combining real-world data to genomic datasets enables discovery of new prognostic biomarkers, and provides clinical evidence within unique populations needed for trial design.

    10 min watch

  • videoAsset 7 Video
    Impacting complex genomic/immune landscapes: Precision medicine in the real-world cancer clinic

    This talk is part of the ResearchX session: Precision Oncology: How RWD is Advancing Clinico-Genomic Research.

    14 min watch

  • podcastAsset 10 Podcast
    Racial and ethnic disparities: What can we learn from RWE?

    In this episode, we examine racial and ethnic disparities through the lens of oncology, real-world data and health policy.

    25 min listen

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